Myrrh is currently used in some liniments, healing salves that may be applied to abrasions and other minor skin ailments.

Myrrh is a constituent of perfumes and incense, was highly prized in ancient times, and was often worth more than its weight in gold. In ancient Rome myrrh was priced at 5 times as much as frankincense, though the latter was far more popular. Myrrh was burned in ancient Roman funerals to mask the smell emanating from charring corpses. It was said that the Roman Emperor Nero burned a year's worth of myrrh at the funeral of his wife, Poppaea.

High quality myrrh can be identified through the darkness and clarity of the resin. However, the best method of judging the resin's quality is by feeling the stickiness of freshly broken fragments to directly determine the fragrant-oil content of the myrrh resin. The scent of raw myrrh resin and its essential oil is sharp, pleasant, somewhat bitter and can be roughly described as being "stereotypically resinous". When burned it produces a smoke that is heavy, bitter and somewhat phenolic in scent, which may be tinged with a slight vanillic sweetness. Unlike most other resins myrrh expands and "blooms" when burned instead of melting or liquifying.

Myrrh was one of the gifts of the Magi to the baby Jesus in the story told in the Christian Bible, Gospel of Matthew. Myrrh was used as an embalming ointment and was used, up until about the 15th century, as a penitential incense in funerals and cremations. It is alluded to in the Christmas carol We Three Kings. The scent can also be used in mixtures of incense, to provide an earthy element to the overall smell, and as an additive to wine, a practice alluded to by ancient authorities such as Fabius Dorsennus. It is also used in various perfumes, toothpastes, lotions, and other modern toiletries.

Naturopathic medicinal uses in oral cavity for infections due to bacteria, fungi and viruses